Six fire engines rushed to the site and are being assisted by a helicopter. Firefighters battling the blaze are using jets and an ultra-high pressure hose. Crews from North West Ambulance service and Greater Manchester Police are also at the scene.
A witness said they heard an explosion coming from inside the building on Holland Street.
Neighbours took to social media to say thay had been told to evacuate as a precaution.
Greater Manchester Fire and Rescue Service said: “We are dealing with a significant incident in Holland Street, Denton.
“The fire involves a three storey warehouse building.
“If local, keep doors and windows closed and avoid the area.”
This is a breaking news story… More to follow