The accident happened between Junction 34 Selby and Junction 35, where the busy road merges into the M18.
YorkshireLive is reporting that the police vehicle involved in the pursuit has collided with a motorway bridge.
The fire service, ambulance and police are all at the scene.
Motorists were stranded for hours as emergency services dealt with the aftermath of the accident.
Two separate diversions were put in place for vehicles above and below 4.8metres to be taken off the closed stretch of motorway.
National Highways Yorkshire confirmed the incident at 11.52pm on Friday (September 3).
Humberside Police tweeted: “Please be aware that the M18 North heading towards the M62 North and M18 North heading towards the M62 West, Langham Intersection, the road is currently closed. Please avoid the area where possible.”
(More to follow)