The Duchess of Sussex, Meghan Markle, 39, and the couple’s son Archie Harrison Mountbatten-Windsor will also feature in the Duke’s episode.
Prince Harry also touches on how the coronavirus pandemic will have taken a huge toll on an individual’s mental health.
“The results of this year will be felt for decades. The kids, families, husbands, wives, everybody,” he says.
This series has been co-produced by the Duke and Oprah, with The Sussexes’ Archewell website stating the reason for the project is to have “honest discussions about mental health and emotional wellbeing, while opening up about their personal journeys and struggles.”
Good Morning Britain airs weekdays at 6am on ITV.