The 15-year-old lad was rushed to hospital but medics were unable to save him. He was attacked at around 4.45am today in Bolton, Greater Manchester, where multiple roads have been closed as police investigate.
No arrests have been made at this stage, Manchester Evening News reports.
Forenisc crime scene officers are currently at the scene.
Detective Superintendent Chris Bridge, of Greater Manchester Police, said: “This incident will understandably be a huge shock to the community and our thoughts are with the boy’s family at this awful time.
“These are very early stages of our investigation but we would like to reassure the public that we are doing all we can to piece together what happened and find those responsible.
“There will be an increased police presence in the area whilst we carry out a number of lines of enquiry and anyone concerned in the local neighbourhood can speak to our officers.
“I would urge anyone who may have information or witnessed anything in the area to come forward. Even the smallest information may be crucial to our investigation.”
The investigation continues.
More to follow.